Neurobiology of Disease Nociceptin/Orphanin FQ Receptor Agonists Attenuate L-DOPA-Induced Dyskinesias
نویسندگان
چکیده
Matteo Marti,1 Donata Rodi,1 Qin Li,2 Remo Guerrini,3 Stefania Fasano,4 Ilaria Morella,4 Alessandro Tozzi,5,6 Riccardo Brambilla,4 Paolo Calabresi,5,6 Michele Simonato,1 Erwan Bezard,2,7,8 and Michele Morari1 1Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara and National Institute of Neuroscience, 44100 Ferrara Italy; 2Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, 100864 Beijing, China; 3Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, 44100 Italy; 4Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University, 20123 Milano, Italy; 5Clinica Neurologica, Dip. Specialità Medico-Chirurgiche e Sanità Pubblica, Università di Perugia, Ospedale Santa Maria della Misericordia, 06123 Perugia, Italy; 6Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, 00179 Rome, Italy; 7Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, F-33000 France; and 8Centre National de la Recherche Scientifique, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, F-33000 France
منابع مشابه
Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias.
In the present study we investigated whether the neuropeptide nociceptin/orphanin FQ (N/OFQ), previously implicated in the pathogenesis of Parkinson's disease, also affects L-DOPA-induced dyskinesia. In striatal slices of naive rodents, N/OFQ (0.1-1 μm) prevented the increase of ERK phosphorylation and the loss of depotentiation of synaptic plasticity induced by the D1 receptor agonist SKF38393...
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Endogenous nociceptin/orphanin FQ (N/OFQ) inhibits the activity of dopamine neurons in the substantia nigra and affects motor behavior. In this study we investigated whether a N/OFQ receptor (NOP) antagonist, J-113397, can modify movement in naive mice and nonhuman primates and attenuate motor deficits in MPTP-treated parkinsonian animals. J-113397 facilitated motor activity in naïve mice at lo...
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By using a battery of behavioral tests, we showed that nociceptin/orphanin FQ receptor (NOP receptor) antagonists attenuated parkinsonian-like symptoms in 6-hydroxydopamine hemilesioned rats (Marti et al., 2005). We now present evidence that coadministration of the NOP receptor antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H benzimidazol-2-one (J-113...
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δ opioid peptide (DOP) receptors are considered a therapeutic target in Parkinson's disease, although the use of DOP agonists may be limited by side effects, including convulsions. To circumvent this issue, we evaluated whether blockade of nociceptin/orphanin FQ (N/OFQ) tone potentiated the antiparkinsonian effects of DOP agonists, thus allowing for reduction of their dosage. Systemic administr...
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